Mak Lab

Molecular Immunology


Andrew Makrigiannis Dal Office

Dr. Andrew Makrigiannis


  • Born in the beautiful maritime city of Halifax, Nova Scotia, Canada, to Greek immigrant parents, Dr. Makrigiannis developed an interest in science in high school and decided to pursue this in university. After having taken his first Immunology class in his third year of undergraduate studies at Dalhousie University, he knew he had found his area of interest.
  • In 1994-1998, Dr. Makrigiannis obtained his Ph.D. in Microbiology and Immunology at Dalhousie University studying the costimulatory requirements of cytotoxic T lymphocyte activation in the laboratory of Dr. David Hoskin.
  • In 1998-2002: Dr. Makrigiannis was a postdoctoral fellow at the National Cancer Institute (NCI) – National Institutes of Health (NIH) in the Laboratory of Experimental Immunology, in Frederick, Maryland, USA under the mentorship of Dr. Stephen Anderson. His postdoctoral work resulted in a NIH Excellence Award for research productivity.
  • In 2002 (to 2009), Dr. Makrigiannis started his own Molecular Immunology laboratory at the Institut de recherches cliniques de Montreal (IRCM) where he supervised many graduate and undergraduate students, as well as teaching at McGill University in the Departments of Microbiology and Immunology and the Department of Physiology.
  • In 2003, Dr. Makrigiannis received a Canadian Institutes of Health Research (CIHR) New Investigator Award, in 2006, the first Canadian Society for Immunology (CSI) New Investigator Award, and in 2008, a Fonds de la recherche en sante Quebec (FRSQ) Junior 2 Award. In 2010, Dr. Makrigiannis was awarded a Canada Research Chair, Tier II in Innate Pathogen Resistance.
  • In 2009 (to 2015), Dr. Makrigiannis moved his laboratory to the University of Ottawa at the Biochemistry, Microbiology, and Immunology (BMI) Department. He was promoted to full professor in 2014 and taught in the BMI Department and the Faculty of Medicine. From 2010 – 2015, Dr. Makrigiannis was the Director of Graduate Studies for Microbiology and Immunology.
  • In 2016 (to present), Dr. Makrigiannis was appointed Head of the Department of Microbiology and Immunology at Dalhousie University in Halifax, Nova Scotia, where his laboratory currently operates.
  • Dr. Makrigiannis is a member of the the Canadian Society of Immunology (CSI) and the Society for Natural Immunity (SNI) and the American Association of Immunologists (AAI) .He has been invited to give research presentations both nationally and internationally.
  • Dr. Makrigiannis has participated in scientific grant review panels including the Canadian Cancer Society Research Institute (CCSRI; formerly National Cancer Institute of Canada, NCIC) and the Canadian Institutes of Health Research (CIHR).
  • Dr. Makrigiannis` lab publications have reported the discovery and characterization of novel class I MHC receptors (Ly49) expressed by natural killer cells and the first comprehensive genetic mapping studies showing Ly49 haplotypes are highly polymorphic. His lab has also produced the first Ly49 gene-disrupted mouse showing the necessity of this gene family in immune responses.  In 2018, the Makrigiannis laboratory reported a critical role for Ly49 molecules in adaptive natural killer cell responses.

Andrew Makrigiannis Teaching MICI 2100 at Dalhousie 2016

Last updated: January 25, 2019